|Also Known As||N-phenylacetyl-L-prolyglycine ethyl ester, GVS-111, Noopeptide|
|Stacks Well With||
|Typical Dose||10–20 mg|
|Chemical and physical data|
|Molar mass||318.367 g/mol g·mol−1|
Noopept is a powerful, fast-acting nootropic that’s an efficient brain booster and a potent neuroprotectant. It’s similar in structure to Piracetam but up to 1,000 times more potent.
What Is Noopept?
Noopept is a powerful synthetic nootropic with proven cognitive enhancement and neuroprotective properties.
Its effects and mechanisms of action are similar to those of piracetam, but Noopept has a different chemical structure and is not technically a racetam.
Like piracetam, Noopept enhances cognition, provides significant neuroprotection, and has both psychostimulant and anti-anxiety properties. The most significant differences between the two are relative strength and speed of action; Noopept is approximately 1,000 times more potent than piracetam, and it is absorbed more rapidly.
Noopept also appears to work faster and last longer than piracetam, and may have fewer undesirable psychostimulatory effects.
Many users say they can feel the effects of Noopept within an hour of ingestion.
Noopept was developed in Russia in the mid-1990s and continues to be used there as a prescription treatment for a variety of cognitive disorders, including traumatic brain injury, cerebral vascular insufficiency, and age-related cognitive decline.
Noopept is unregulated in both the US and Canada.
Benefits and Effects of Noopept
Memory and Learning
Noopept was developed as a treatment for cognitive impairment, and it is best known as a brain booster and memory enhancer.
Like piracetam, Noopept assists with memory formation, but with additional benefits including enhanced memory consolidation and retrieval.
According to Russian pharmaceutical product information, Noopept improves learning ability and memory by acting on all phases of processing, from initial information processing to consolidation and extraction.
Most research on Noopept’s effects on memory has been done on models of cognitive decline or brain damage, and it has been used successfully in Russia to treat a variety of cognitive impairments, including stroke, organic brain disease, age-related neurodegeneration, and alcohol-related brain damage.
At present, there are no documented studies on Noopept’s cognitive enhancing effects on healthy humans, but anecdotal reports from users taking Noopept for its nootropic effects are positive.
Some users also report improved sensory perception, including enhanced vision and hearing.
Increased Levels of NGF and BDNF
In animal studies, Noopept has been shown to stimulate the expression of two important cognition-related chemicals, Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF).
NGF is a unique protein that is crucial to the growth, maintenance, and survival of nerve cells, including brain cells. NGF is a key component in neurogenesis, or the body’s ability to create new nerve cells.
Neurogenesis is known to improve the performance of neural networks within the brain, and better brain structure is associated with enhanced performance in virtually all areas of cognition. Low levels of NGF are associated with a host of disorders, including dementia, Rett syndrome, schizophrenia, Alzheimer’s disease, and bipolar disorder, as well as acute coronary and metabolic syndromes.
Brain-Derived Neurotrophic Factor (BDNF) has a similar role to NGF but is primarily active in the hippocampus, cortex, and basal forebrain, areas of the brain that are vital to learning, memory, and higher thinking. BDNF is one of the most important molecules involved in memory, playing a vital role in both short-term and long-term memory formation.
Various studies demonstrate that Noopept has powerful neuroprotective properties that help protect the brain from a variety of factors that can impair cognition.
Noopept is a potent antioxidant that protects cells against oxidative damage from free radicals, incomplete molecules formed when the body is exposed to contaminants or stressors. Oxidative damage is closely associated with age-related cognitive decline and neurodegenerative disorders such as Alzheimer’s disease.
Noopept is also an effective anti-inflammatory agent,which may further protect and enhance cognition; systemic inflammation is associated with loss of spatial reasoning, short-term memory, verbal proficiency, verbal learning and memory, and executive function.
In addition, Noopept protects and promotes neurological health by improving blood flow to the brain and inhibiting neurotoxicity caused by excess calcium and glutamate.
There is evidence that Noopept may be able to reduce anxiety.
Animal studies suggest that subjects treated with Noopept appeared to have significantly lower anxiety levels,and in a human study of patients with mild cognitive disorders, 10 mg of Noopept twice daily resulted in anxiety reduction.
Self-reports from users vary on Noopept’s anxiolytic ability. Some users say they find it relieves anxiety, while others say Noopept makes them feel anxious.
How It Works
Noopept is metabolized in the liver, rapidly absorbed by the digestive system, and readily crosses the blood-brain barrier.Noopept acts quickly once it is in the bloodstream, maximizing concentration after just 15 to 20 minutes.
Noopept’s exact mechanisms of action are not completely understood, but it appears to work in the brain in several ways. It is believed to have a sensitizing effect on acetylcholine processes, effectively increasing the neural response to acetylcholine, the neurotransmitter most closely associated with learning and cognition.
It has also been shown to increase the expression of both NGF and BDNF, two important neurotrophin proteins that play a vital role in cognition and memory.
Animal studies further suggest that Noopept modulates the activity of both AMPA and NDMA receptors, which regulate brain levels of the excitatory neurotransmitter glutamate.This action not only prevents glutamate toxicity, which can lead to neuronal damage, it also enhances neuroplasticity, which is crucial to the formation of long-term memories.
Noopept has been shown to have significant antioxidant and anti-inflammatory capabilities, which make it a powerful neuroprotectant.
Noopept also promotes the elimination of excess glutamate and calcium while improving blood composition and flow.
The standard dose of Noopept is 10 mg, taken twice per day after a meal. Dosage may be increased to 30 mg per day if necessary.
Taking Noopept late in the evening may interfere with sleep.
The recommended course of prescription Noopept treatment is 1.5 to 3 months. If necessary, another cycle may be started after a 1-month break.
It is recommended to start with the minimum effective dose and only increase the dosage as needed. Some users report that higher doses diminish the desired cognitive effects of Noopept.
User experiences differ on whether or not prolonged uninterrupted use of Noopept leads to tolerance. Many users say they take Noopept in cycles to prevent tolerance.
Noopept can be taken alone but also does very well in nootropic stacks for additional synergistic benefits.
Noopept, Piracetam, and Choline Stack
Because Noopept delivers results similar to piracetam, stacking the two may result in synergistic benefits.
The two nootropics work on two different neurotransmitters, glutamate and acetylcholine, respectively. The enhanced functionality of both transmitters could create a boost to a variety of cognitive processes.
Furthermore, adding a choline supplement to the stack could make the piracetam more effective and help prevent headaches reported by some initial-stage Noopept users.
1x–2x per day
- 10 mg Noopept
- 2 g Piracetam
- 300 mg Alpha GPC
Noopept, Aniracetam, Sulbutiamine Stack
Stacking Noopept with aniracetam and sulbutiamine would be a powerful stack that may not only boost cognition but also provide improvements to mood as well as reduce anxiety.
These effects on mood and anxiety should also indirectly lead to improved creativity and mental performance due to the relaxed mindstate.
Sulbutiamine should be cycled to avoid building up a tolerance to it.
1x–2x per day
- 10 mg Noopept
- 750 mg Aniracetam
- 200 mg Sulbutiamine
- 300 mg Alpha GPC
Noopept is generally considered safe and well tolerated, with only minor side effects, including headaches, restlessness, dizziness, and irritability. These are most common when Noopept is taken in high doses.
Some users report that Noopept temporarily impairs short-term memory when taken above recommended dosages.
Noopept is contraindicated for women who are pregnant or lactating, people with lactose intolerance or kidney or liver malfunction, and children under 18 years of age. Noopept may also increase blood pressure in individuals with hypertension.
Noopept is a popular nootropic with a growing user base.
It’s effective and well-tolerated, and its standard low dosage makes it both affordable and easy to use. It works well on its own, and it shines in combination with other nootropics, which makes it a popular choice for stacking.
Most side effects are related to high doses, and the possibility of developing tolerance is easily managed through cycling.
Whether you’re an experienced nootropic user or just getting started, Noopept may be worth your consideration.
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