Epithalon (Epitalon) 50mg
Epithalon Tetra Peptide Sequence: alanyl-glutamyl-aspartyl-glycine
Molecular Formula: C14H22N4O9
Molecular Weight: 390.34588
Epitalon Tetra Peptide
Epithalon is a peptide used to regulate the cell cycle through up-regulation of telomerase activity. The sequence of amino acids in the peptide is Alanine-Glutamate-Asparagine-Glycine. Animal studies have been done on the effects of Epithalon on suppression of spontaneous mammary tumors and spontaneous carcinogenesis. Studies have shown that the mode of action of Epithalon involves suppression of oncogene expression and modification of telomerase activity. A summary of the studies and research on telomerase is provided below.
Telomerase is a specific RNA (ribonucleic acid)-dependent polymerase that elongates and maintains the length of telomeres by adding tandem repeats on the chromosomal 3′ end. The enzyme is composed of two parts: an RNA component which supplies the telomere template for elongation, and the catalytic subunit which possesses reverse transcriptase activity. These two parts work in tandem to avert telomere attrition especially in somatic cells. In vitro experiments have shown that telomere elongation promotes indefinite cellular proliferation and that suppression of telomerase activity promotes apoptosis of neoplastic cells. However, these studies have also shown that maintenance of telomere length within a range of 15-20 kilobase pairs does prevent tumorigenesis. All the research and studies done concerning telomerase do show that telomerase activity is limited to cell division through its action of stabilizing the telomere length.
Telomeres are located at either ends of a chromosome, and they do protect the adjacent gene sequence from shortening due to repeated replication cycles. Elongation of telomeres enables senescent cells to stabilize their telomeric length. However, excess elongation would enable such cells to exceed their Hayflick limit via evasion of apoptosis or the post-mitotic phase; and therefore, such cells have the potential of becoming immortal and this predisposes them to neoplastic transformation.
Human telomeres are made up of tandem repeats of the nucleotide sequence TTAGGG that form a T loop structure when associated with telomere-binding proteins. The T loop structure ensures the integrity of the telomeres by protecting them from constitutive degradation. These tandem repeats do shorten as a consequence of repeated chromosomal replication cycles. Such shortening is due to the inability of DNA polymerase to repeatedly replicate the nucleotides located in the T loop region. This leads to senescence or growth arrest, and a critically shortened telomere does induce a p53-mediated DNA checkpoint reaction. Some cells do evade senescence if they have nonfunctional p53 and/or pRb, but cell death still occurs due to either lethal DNA rearrangements or chromosomal fusion. Thus, evasion of telomere-mediated senescence is the main way that cells use to avert premature senescence and apoptosis. This occurs only when telomerase activity is up-regulated. Telomerase elongation leads to stabilization of the genotype as the rate of gene mutation is maintained within normal limits. However, an increase in the rate of apoptosis leads to a proportionate increase in cellular regeneration rate, and this causes an increase in the number of sporadic gene mutations that occur thus predisposing the person to pro-neoplastic mutations.
Current studies show that telomere shortening is associated with chronic diseases such as pulmonary fibrosis, coronary artery disease, diabetes mellitus and Alzheimer’s disease, though their findings are still considered inconclusive. Based on the findings of these studies, it can be theorized that Epithalon could prevent the development of these diseases.
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Peptides due to their nature come in a variety of sizes and shapes. Normally after the lyophilization process has completed we have a peptide that is in a perfect cake. However there are times when it may break in transit or simply appear differently. This is no way effects the quality or potency of the product. It is simply an aesthetic issue. While we do try to always present a product that looks perfect, on occasion this isn’t possible. Proteins such as LR3 are very large in size and due to the requirement of a buffer will appear larger in size than a mod grf or ghrp. This is also normal.
If A Peptide Is 98% In Purity Then What Is The Remaining 2%?
The purity level indicated on a COA is simply a measurement of aminos that made it into the proper chain to form the peptide. The left over 2% are simply aminos that, for what ever reason, didn’t make it into the proper sequence.
What Are The Purity Levels Of The Peptides You Sell?
AP PEPTIDE will never sell a peptide that is less than 98% in purity from our catalog section. Many of our smaller peptide chains are well into the 99% purity range. We have manufacturing abilities that are quite often beyond the scope of smaller companies and therefore are able to achieve very high purity levels. Proteins such as IGF-1 LR3 are always receptor grade and always above 95% purity.
Two Vials Of The Same Peptide Have Different Amounts Of Powder. Does This Mean They Are Different In Milligrams?
Peptides, due to their nature, come in a variety of sizes and shapes. Normally after the lyophilization process has completed we have a peptide that is in a perfect cake. However there are times when it may break in transit or simply appear differently. This in no way effects the quality or potency of the product. It is simply an aesthetic issue. While we do try to always present a product that looks perfect, on occasion this isn’t possible.
Proteins are very large in size and due to the requirement of a buffer will appear larger in size than a mod grf or ghrp. This is also normal.
What Are Your Products Used For?
Peptides and Research serums are manufactured and sold to be used in a laboratory research setting. None of our products are intended for, nor are they manufactured for, diagnostic or therapeutic purposes in humans. Strong Peptide reserves the right to require additional verification of proper intent prior to fulfilling orders. Any orders that we feel aren’t for the specific intended purpose laid out in our Terms and Conditions will be denied. Truthfully, if you are asking this question then you shouldn’t be ordering from AP PEPTIDES.